Magnesium Pidolate And Brain Penetration
The dysfunction of the bloodbrain barrier has been described in several neurological disorders, including ischemic stroke and inherited and neurodegenerative diseases . This topic remains controversial: while some studies did not find changes in BBB during a migraine attack , there are studies in human subjects and animals that indicate that BBB permeability may be increased with migraine and headaches . BBB disruption has been associated with magnesium deficiency in the brain . It is therefore interesting to distinguish agents that exert a protective role on BBB and prevent its impairment in response to various challenges. There is evidence that magnesium has a protective role on the BBB in vivo , and a recent paper has highlighted that 10 mmol/L magnesium sulfate reduces the permeability in an in vitro model of the human BBB . This effect could be the result of the antagonism between calcium and magnesium in the endothelial actin cytoskeleton, which remodels intercellular gap formation, thus inhibiting the paracellular movement of molecules through the tight junctions .
Romeo et al. compared the effect of different magnesium salts at the same concentration in in vitro in models of rat and human BBBs. All salts decreased BBB permeability among them, magnesium pidolate and magnesium threonate were the most efficient in the rat model, and magnesium pidolate was the most efficient in the human model, suggesting differences in response between humans and rodents.
Dehydration Could Be The Culprit When It Comes To Your Headaches
Weâre surrounded by drinking water, yet many of us donât get enough of this important fluid during the day. And some people donât drink any fluids for hours and hours, which registered dietician MEd, CSSD, LDN, CDE told INSIDER can be a contributing factor in headaches.
âIf you fall in this category, consider setting the alarm on your phone or computer to cue you to drink,â recommended Stefanski. She said to focus on drinking eight ounces of water several times per day. âEveryone has different fluid needs, but you should aim for at least 64 ounces of fluid as an adult,â she explained.
Read more: 11 signs of dehydration you might be missing
So What Are The Best Forms & Ways To Use Magnesium For Dizziness
Below youll find my favorite ways to be sure Im getting enough magnesium for dizziness. I follow the magnesium dosage recommendations from Johns Hopkins Headache Center. In the beginning I took 800mg per day. Now that my symptoms are controlled, I have been able to save a little money by backing off that dose. Now I take 240-360mg a day with added foot soaks and topical magnesium on bad days.
Also Check: What Is A Migraine Headache
Best Food Sources Of Magnesium
According to the National Institutes of Health, some of the best food sources of magnesium include:
- Pumpkin seeds
- Chia seeds
- Peanut butter
Yogurt, breakfast cereals, oatmeal, bananas, salmon, milk, raisins, avocados, beef, broccoli, rice, and apples also have significant doses of magnesium.
Magnesium Supplements For Your Migraines
This all being said, some organizations, like the Canadian Headache Society, recommend magnesium as a preventive migraine therapy in adults. In fact, the Canadian Headache Society suggests a specific magnesium dose600mg of elemental magnesium daily.
On the other hand, while the American Headache Society and the American Academy of Neurology reported magnesium as “probably effective” in preventing migraines in their 2012 guidelines, they do not give recommendations on a specific dose.
This is probably because the scientific studies examining magnesium supplementation in migraine prevention have used different doses. So it’s hard to pinpoint exactly how much magnesium a person needs to prevent migraines, and it likely varies by the person .
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How To Use Magnesium For Migraines
People with migraines can take magnesium oxide in the form of a pill to supplement their magnesium intake.
Alternatively, a doctor may administer 12 grams of magnesium sulfate intravenously if a person is having problems absorbing it.
Other forms of magnesium include:
- magnesium carbonate
- magnesium chloride
- magnesium citrate
The body absorbs these different types of magnesium at different rates. The body has difficulty absorbing magnesium unless it is bound to something else, so magnesium supplements often contain other substances, such as amino acids, that also provide health benefits.
Some people prefer to boost their magnesium intake through their diet.
Foods that contain magnesium include:
- nuts and grains
Magnesium occurs naturally in many foods. Increasing magnesium levels by eating more of these foods does not appear to have any associated risks.
However, taking too many magnesium supplements can cause some adverse effects, including diarrhea, cramps, and vomiting.
If a person experiences diarrhea due to a magnesium supplement, they should stop taking it. It is also essential for a person with diarrhea to stay hydrated.
People should also avoid taking magnesium supplements alongside a type of antibiotics known as aminoglycosides. Taking these substances together can cause muscle weakness and other problems.
An excessive buildup of magnesium in the body can lead to severe side effects, including:
- an irregular heartbeat
What Should I Be Cautious Of
Magnesium supplements are relatively safe , but that doesnât mean theyâre for everyone. People with reduced kidney function or certain neurological disorders should not take magnesium without first discussing it with their doctor.
In addition, magnesium supplements can interfere with your bodyâs ability to absorb some medications, so talk to your doctor before starting if youâre taking any of these medications:
- bisphosphonates, which are used to treat osteoporosis
- prescription medications for acid reflux or peptic ulcers
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What Types Of Magnesium Are Available
Because magnesium is unstable by itself, it likes to be combined with other minerals to form what is called a salt.
Magnesium can also be combined with organic acids to form magnesium acid complexes or with amino acids to form magnesium chelates.
Depending on what chemical is combined with magnesium, the bioavailability might change.
Bioavailability basically means the amount of a substance that is absorbed by the body. So, if a supplement has HIGH bioavailability, then most of it is absorbed.
There are MANY types of magnesium available to choose from, so weve broken down some of the most common forms below.
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Many people take magnesium supplements daily for optimal health.
Magnesium is an essential mineral and an electrolyte. Although magnesium supplements arent known as turmeric or zinc supplements, magnesium supplements have surged in popularity.
Magnesium deficiency is associated with unpleasant side effects. If you dont get enough magnesium from your diet, then a magnesium supplement could help.
We ranked, analyzed, and tested the worlds most popular magnesium supplements. Here are our rankings.
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Are There Any Risks In Using Magnesium For Migraines
Magnesium may cause negative reactions when taken with antibiotics, as it can interfere with their absorption. Taking magnesium supplements alongside certain antibiotics, such as aminoglycosides, can cause other problems, including muscle weakness.
Taking too many magnesium supplements can also lead to side effects such as cramps, diarrhea, and vomiting. If you experience diarrhea with a magnesium supplement, stop taking it, and stay hydrated to restore any lost fluid.
People with certain medical conditions may experience additional side effects while taking magnesium. These conditions include:
Excess magnesium in the body can also cause irregular heartbeat, slowed breathing, and coma.
Always consult a health care provider before taking any new supplements, including magnesium.
Can Magnesium Help Prevent Migraines
According to multiple scientific studies, the American Headache Society, and the American Academy of Neurology, the answer is yes. Not every clinical trial has shown magnesium to be effective at preventing migraine headaches, but thereâs enough evidence that it helps that itâs a good option to consider.
How can it help? Experts think magnesium may help prevent the wave of brain signaling, called a cortical spreading depression, that is thought to cause migraines. It can also reduce pain during a migraine attack by blocking pain-transmitting chemicals in the brain.
Research suggests that itâs especially helpful for people who have migraines with aura or menstrual migraines. Scientists believe it may help prevent aura by stopping your brain from producing the signals that cause it, but they arenât quite sure why itâs so effective against menstrual migraines.
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What Is The Best Magnesium For Migraines
Did you know that roughly 1 out of every 6 Americans suffers from migraines ?
Migraines are severe headaches that are often accompanied by symptoms such as nausea, vomiting, sensitivity to light or sound, and vision disturbances.
Unfortunately, there is no definitive cure for migraines , so treatment is usually focused on reducing the number of attacks and managing symptoms.
Medications, such as over-the-counter painkillers and prescription drugs, are often used to treat and prevent migraines, but natural remedies are becoming more popular.
One promising option for those seeking natural migraine relief is to try magnesium supplements.
In this article, well explain the link between magnesium and migraines and tell you which magnesium supplement is best for preventing migraines.
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Are Magnesium Supplements Safe
Studies suggest magnesium supplements are safe, but they can cause some mild side effects, including diarrhea, nausea, and stomach cramps. And hereâs another good reason to let your doctor know if you take magnesium supplements: They donât always work well with drugs for other conditions like bone health, infections, high blood pressure, and chronic heartburn.
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Best Supplements For Migraine Relief
The content and opinions on Top10Supps are meant to be informative only. They are not medical advice or intended for the diagnosis, prevention, and/or treatment of any health problems. We may receive a commission if you buy something using a link on this page.
A migraine is an intense and prolonged headache, which usually lasts from between 4 and 72 hours . They can be accompanied by other symptoms, such as nausea, vomiting, sensitivity to light, sound, and odor. They can also occur with or without aura . Physical activity can also increase the severity of pain .
Migraines are socially and financially debilitating, for both individuals and society as a whole . They occur more often in women as a result of hormonal influences . The main cause of migraines is unknown but a variety of genetic and environmental factors are involved in their development . We also know that there are different types.
The Link Between Vitamin D And Migraines
Many young adults, teens and children who get frequent migraines were more likely to have lower levels of vitamin D, riboflavin and coenzyme Q10, than people who dont get migraines, found a recent study. A vitamin D deficiency showed up in 70% of the patients, while 30% had coenzyme Q10 levels at the low range and 15% had riboflavin levels below normal. The boys and men in the study were more likely to have vitamin D deficiencies, while the girls and young women were more likely to be low in coenzyme Q10.
Though the results are intriguing and offer hope to people who experience serious migraines, its too early to say if taking a vitamin supplement is all you need to do to prevent migraines. The patients in this study who had vitamin deficiencies took a daily vitamin, but they were also taking prescription migraine medications at the same time, so it was not possible for researchers to test if vitamin supplementation on its own would be effective.
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Magnesium Levels In Migraineurs
For many decades, it was postulated that magnesium deficiency played a role in migraine pathogenesis. However, the lack of simple and reliable measures of magnesium levels prevented further research to prove this theory. While low serum, cerebrospinal fluid and cerebral tissue levels of magnesium have been found to be low in patients with migraine , these results have been inconsistent, with both normal and low levels detected in the same tissues of some patients. The variability of results may be due to the need to measure ionized magnesium as a true reflection of magnesium metabolism, and the development of an ion selective electrode for ionized magnesium in whole blood, serum, plasma and aqueous samples has made an accurate and rapid measurement of ionized magnesium levels possible .
How Can You Know If Youre Magnesium Deficient
Measuring magnesium levels in the body is difficult because most of the mineral is stored in cells and bone. Our bodies use just whats needed and store the rest in these locations.
The best available way of determining a persons magnesium levels is with a magnesium RBC test, also known as a magnesium blood test. As its name suggests, this test measures the levels of magnesium found in a persons red blood cells. If you want to know whether you are magnesium-deficient, you can ask your doctor to test your levels.
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What Is A Migraine
In case there was any doubt of just how painful they can be, The World Health Organization lists migraines as one of the 10 most disabling medical illnesses on the planet. The takeaway? Migraines are no joke.
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Magnesium is, by far, at the top of the list of minerals your body requires. It is much needed for proper muscle and nerve function, blood glucose regulation, and heart health. There is even solid evidence that magnesium can help prevent migraines and lower your risk of developing type 2 diabetes. Where exactly does magnesium come from? Magnesium, on the other hand, is naturally found in plant and animal foods. More than 50% of your magnesium is in your bones, one-fourth is in your muscles, and the rest is in fluids and tissues like your blood, heart, and kidneys.
The magnesium in bone serves not only to maintain its structure but also acts as a reservoir that can be appropriately used to ensure an adequate blood supply of the mineral to the rest of the body. You can get your magnesium fix by eating certain foods and, if necessary, taking a dietary supplement. According to the National Institutes of Health, adult males require 400 to 420 milligrams per day, while adult females require 310 to 360 milligrams per day . Nuts and seeds, spinach, soy milk, black beans, edamame, baked potatoes, and brown rice are high in the mineral.
Magnesium deficiency has been linked to unpleasant side effects. If you dont get enough magnesium from your diet, a magnesium supplement may be beneficial.
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Magnesium And Your Migraines
Magnesium is a mineral involved in the functioning and health of many parts of your body, including your muscles, bones, heart, and nerves. A deficiency of magnesium has been linked to a number of health problems, including migraine development.
In the United States, magnesium deficiency is actually quite common and is mostly due to an increased intake of processed and refined foods, which are naturally low in magnesium.
A number of medical problems can also contribute to magnesium deficiency, like alcohol abuse, kidney disease, celiac disease, inflammatory bowel disease, and certain medications like proton pump inhibitors .
While magnesium deficiency has been linked to migraine development at a basic scientific level , experts aren’t quite sure how that science translates to the clinical level .
There are likely many factors involved in a person’s migrainesa very complex neurological disease. So while magnesium deficiency may make certain people more vulnerable to developing migraines, it probably is only one piece of the puzzle.
Why Migraine Cutis Produced As A Migraine Nasal Spray
Its spray form has positive effects on product effectiveness. Some advantages of this natural Migraine Medication spray:
Increase the effectiveness of the drug
Impact on the brain by olfactory neurons
Access to the lymphatic system
Prevent the drug entrance to gastrointestinal and damage to the drug active ingredients
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Magnesium Benefits: What Does Science Say
Magnesium is an essential mineral for health and wellness. Studies have validated the use of magnesium, the risk of magnesium deficiency, and the benefits of a magnesium-rich diet. Well explore some of those benefits below to explain how magnesium supplements may be able to help.
One large meta-analysis found that a dose of 300mg of magnesium per day for one month was associated with a reduction in systolic and diastolic blood pressure. In another study, researchers reviewed the evidence on magnesium supplementations. They found that taking 365mg to 450mg of magnesium per day for 1 to 6 months lowered blood pressure in individuals with insulin resistance, type 2 diabetes, and other severe health conditions. Because of these studies and others, many magnesium supplements are advertised to support cardiovascular health.
Some people with diabetes take magnesium supplements, and studies have validated the use of magnesium in some people with diabetes. In this study, researchers found that supplementing with magnesium for four months could improve glucose control and insulin resistance while increasing insulin sensitivity in some individuals. Researchers also found magnesium supplementation was associated with better metabolic health and a reduced risk of type 2 diabetes.