Women With Endometriosis Had Higher Rates Of Autoimmune Conditions
Another study conducted in the U.S. involved surveying 3,680 members of the Endometriosis Association. Compared to the general population, women with endometriosis were found to have higher rates of hypothyroidism , fibromyalgia , chronic fatigue syndrome , rheumatoid arthritis , systemic lupus erythematosus , Sjögrens syndrome , and multiple sclerosis .
Two conditions that were not found in higher rates among the women with endometriosis were diabetes and hyperthyroidism. Although this study found the rates of RA were higher in women with endometriosis compared to the general population, the rate increase was slight.7
What Is The Risk Of Stroke With Migraine
Fortunately, the absolute risk of migraine-related stroke is low. In the U.S. the yearly number of strokes from all causes is about 800,000 in a population of over 322 million persons. The yearly risk of stroke in women with migraine is about 3 times what it is for women without migraine, with an estimated 13 strokes per 100,000 women that are tied to migraine rather than to another diagnosis. This means that out of 28 million women in the U.S. with migraine, the number of stroke per year related to that diagnosis is about 3600, which is less than 1 percent of the total strokes affecting women.
Similarities Between Ra And Endometriosis
Both RA and endometriosis are characterized by chronic inflammation. Inflammation is a normal response of the immune system to trauma or foreign invaders like bacteria. However, in autoimmune diseases, the bodys immune system is switched to react to itself, creating chronic inflammation that can damage tissues. While endometriosis has not been classified as an autoimmune disease, some researchers make a case that it acts like one.3
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Migraine And Other Risk Factors
Vascular risk factors like hypertension, heart attacks, and stroke are known to be associated with the development of dementia, and vascular risk factors have also been associated with migraine.1 Migraine has been shown to be risk factors for cardiovascular disease as well.1 There is an overlap between all of these events and risk factors that lend credence to the association found between migraine and dementia and Alzheimers disease.
In this particular study, vascular factors did not appear to be a component of the association found. One explanation for the relationship may be that chronic migraine can lead to neurological damage, leading to subsequent cognitive issues and impairment, particularly in the cognitive domains affected by migraine.1 More research is needed to further explore this, however.
Another possible component of the association between migraine and dementia and Alzheimers disease are genetic factors. Those with familial Alzheimers disease caused by presenilin-1 mutations are more likely to experience migraine or recurrent headaches.1 Chromosomes 1 and 19 are also associated with both migraine and Alzheimers disease.1 More research on genetics may provide more detailed information on the link between migraine and Alzheimers disease.
Migraine Postdrome And Dopamine
Postdrome symptoms such as mood changes, drowsiness, and tiredness could also be due to dopaminergic activation. According to the research, the prevalence of RLS in people with dopaminergic prodrome symptoms is 5 times greater than migraine patients without those prodrome symptoms.3
So I gather if we are prone to having those symptoms, we are more at risk for RLS. I know those are definitely symptoms I experience often.
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Keep A Food Diary To Identify Food Triggers
For both migraine and IBS, foods and beverages can trigger symptoms.
For IBS, dietary advice includes avoiding dairy products, fatty foods, caffeine, and gas-producing foods such as beans and cruciferous vegetables, DeVito says.
Trigger foods can have a domino effect, warns Spears. Often, if someone has IBS and consumes foods that trigger an attack for example, spicy food it will often lead to a migraine attack as well, says Spears.
Keeping detailed records of what you eat and how you feel afterward will help you pinpoint food triggers of your migraine and IBS symptoms.
Link Between Migraine And Cognition
Individuals experiencing migraine often report subjective cognitive decline. Migraine has been shown to particularly affect processing speed, attention, memory, verbal skills, and executive function.2 It also affects processing speed and visuomotor speed, as well as delayed verbal memory and basic attention.2 Compared to periods where an individual does not have migraine, the periods where migraine occurs shows a marked increase in cognitive impairment.
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Similar Features Of Endometriosis And Headache
Although migraine and endometriosis clearly affect different parts of the body, they share some clinical and epidemiological features, most of which probably can be accounted for by the influence of female sex hormones on both disorders.
Early menarche seems to be a risk factor for both headache and endometriosis . For headache, it is of interest that age of menarche seems to influence the prevalence of headache, not only among adolescents but throughout life . Both psychological factors related to early physical maturation, as well as physiological factors related to higher estrogen levels or to increased estrogen sensitivity, have been invoked to explain why headache is more prevalent in females with early menarche. In the case of endometriosis, if the theory of retrograde flow of menstrual blood is true, all conditions that lead to more menstruations will give a higher prevalence of endometriosis.
It also should be noted that headache is commonly listed as a side effect of GnRH-a for treatment of endometriosis, but there seems to be less headache with this treatment than with danazol . In general, when headache is reported as a side effect, one often may question whether it is caused by the drug or whether it occurs incidentally during the drug treatment.
Common Fertility Condition Linked To Migraines
A common condition affecting fertility in women may be linked to migraine, new research reveals. The work could also help scientists understand the origins of migraine.
Women with endometriosis were more than twice as likely to suffer migraine as women without the condition, observed gynaecologist Simone Ferrero and colleagues at the University of Genoa in Italy.
Endometriosis is a common condition where the endometrial tissue which forms the lining of the womb develops outside the uterus and attaches itself to organs and ligaments in the abdominal cavity. This can lead to painful bleeding and inflammation and can cause infertility.
Ferrero says about 5% of women of reproductive age have endometriosis, and between 15% and 19% of this same age group suffer migraine. In light of the findings of the study, the two conditions together would be likely to affect around two in every 100 women of reproductive age, he says.
Anne MacGregor, director of clinical research at the UKs City of London Migraine Clinic calls the study a very interesting piece of work. She adds& colon It could help us understand the pathophysiology of migraines.
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Who Is At Risk
The main type of migraine associated with stroke is migraine with aura, a subtype affecting about 25% of persons with migraine. The main type of stroke associated with migraine is ischemic stroke but persons with migraine also have an increased risk of hemorrhagic stroke . Women with aura are 2 to 3 times more likely to have stroke than women without migraine, all other things being equal. Women with aura are also at higher risk of stroke than men with aura. Interestingly, young persons are at greater risk for migraine-related stroke than are older individuals, and the strongest association of migraine and stroke is in persons without traditional stroke risk factors such as high blood pressure, diabetes mellitus and high cholesterol.
Padma Lakshmi Endured A 3
Top Chef host Padma Lakshmi has been open for years about her endometriosis diagnosis. The condition, which causes tissue that normally grows inside the uterus to grow outside of it, is known to cause terrible cramping and pelvic pain. But it can also trigger serious migraines, as Lakshmi revealed this week on Instagram.
“Day 3 of endo induced migraine from clenching teeth due to cramps….even my ear hurts,” she captioned a photo on that featured her partially covering her face with her arm.
It’s estimated that over six million American women have endometriosis. The condition can cause cysts and scar tissue to develop, which often leads to intensely painful periods. But endometriosis can also cause several unexpected symptomsincluding migraines.
Experts are still debating what causes endometriosis. Although the condition is characterized by tissue growing outside of the uterus, doctors are in disagreement over whether or not it’s actually endometrial tissue or something similar, but not quite the same.
In a person with endometriosis, this tissue can grow onto various organs, womens health expert Jennifer Wider, M.D., tells SELF. It is often found on the ovaries and fallopian tubes but it can grow anywhere. Therefore, the symptoms will vary from person to person, she says.
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Similarities Between Endometriosis And Ibd
Due to the similarities between endometriosis and IBD, it can be difficult for doctors to distinguish and correctly diagnose these two conditions.5 Both endometriosis and IBD are considered chronic inflammatory disorders, and for both conditions, symptoms typically begin in early adulthood. Intestinal endometriosis and IBD also share several symptoms, including abdominal cramps, abdominal pain, diarrhea, and rectal bleeding.5,10,11,12 However, while approximately 10% of US women will experience endometriosis, only 0.5% of the US population will be diagnosed with IBD.3
Migraines Endometriosis And Adhddo You Have All 3
Edit: just saw the fibromyalgia thread, which I never really heard of. And damn, the symptoms sound basically like a person who has migraines with auras, endo, and adhd. I dont know really anything about it, but can someone explain how its not just the co-occurrence of those 3 things?
Im just curious. I feel like a hypochondriac sometimes because I have all 3 and they are so close to what other women experience that I feel like Im just being a baby and not able to handle normal life stuff. I mean, it seems so unlikely to have all 3. Then, I saw somewhere that 2 of them were comorbid. So I did more researchtheres been recent studies showing a high comorbidity rate with adhd+migraine & migraine+endo. Maybe theres not a connection between all 3, but Im just curious about your experiences.
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What Are The Causes Of Endometriosis
The causes of endometriosis vary and are poorly understood. Doctors still dont know everything that can trigger this condition. Causes are a combination of factors including genetics and immune dysfunction.
Endometriosis has not yet been classified as an autoimmune condition but it may increase risk for autoimmune conditions. The inflammatory nature of endometriosis seems to trigger an imbalance in the immune system.
Our immune system protects our body from invaders, but immune systems can get out of balance. If you have an autoimmune disease, your body attacks itself, as if it were a foreign invader. Inflammation can be a part of this autoimmune response.
Having endometriosis may increase your risk for other health conditions. Some of these conditions, called comorbidities, are autoimmune conditions.
How Are Autoimmune Conditions Allergies And Fibromyalgia Related To Endometriosis
The exact mechanism by which endometriosis is associated with autoimmune conditions, allergies, and fibromyalgia is not well understood, however, many studies have suggested that a correlation exists.6-9 This means, although we don’t know why, that those with endometriosis often also have at least one, if not more, of these additional conditions. The autoimmune conditions most often associated with endometriosis are systemic lupus erythematosus , inflammatory bowel disease , rheumatoid arthritis, Sjogren’s syndrome, multiple sclerosis, and Hashimoto’s thyroiditis .6
Since a proposed cause of endometriosis is an altered or faulty immune response that allows endometrial tissue to grow in other places within the body, some researchers suggest that this may be the key to the relationship between endometriosis and autoimmune conditions and allergies. Since both autoimmune conditions and allergies involve issues with immune system functioning, these issues may be the underlying link between these conditions. However, much more research needs to be completed for this hypothesis to be strengthened, especially since an immune system-related issue is only one of many potential contributing factors to the development of endometriosis.6-8
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Prevalence Of Headache In Women With And Without Endometriosis
The prevalence of headache was significantly higher among women with endometriosis than in the control group . When the different types of headache were considered, only migraine was significantly more frequent among women with endometriosis than in the control group . In particular, migraine with aura was observed in 18 women with endometriosis and in two control subjects .
No significant difference was observed in the prevalence of migraine among women with mild and severe endometriosis . Among women with endometriosis, there was a trend for the prevalence of migraine to be higher in subjects with dysmenorrhoea, deep dyspareunia and/or chronic pelvic pain than in women without pain symptoms , but the difference was not statistically significant .
Endometriosis As A Catch
Looking ahead, the Society for Womens Health Research recommends more funding and research be dedicated to understanding the underlying biology of endometriosis and its subtypes in hopes of finding new therapeutic avenues. To get into the specifics, PPM Editor Angie Drakulich spoke to Sawsan As-Sanie, MD, MPH, lead author of the SWHR’s report.1 Dr. As-Sanie serves as the director of the University of Michigan Endometriosis Center and an associate professor and director of the Minimally Invasive Gynecology Division and Fellowship in the universitys Department of Obstetrics and Gynecology. She is also a member of the SWHR Network on Endometriosis and Fibroids.
PPM: Why do you think there is such a lack of understanding and funding for researching endometriosis, despite its significant impact on the population and healthcare costs? Do you think it simply falls under the general its a womens issue so its less important umbrella?
PPM: The SWHR report notes that comorbidities are highly prevalent in endometriosis patients. What types of comorbidities are most common?
We also know that women with endometriosis are more prone to autoimmune diseases like Lupus and also more likely to develop cardiovascular disease. While the links between these conditions are not completely clear, one theory is that since endometriosis is associated with both pelvic and systemic inflammation, that this underlying inflammation predisposes women to develop some of these other conditions.
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Neurotransmitter Serotonin Is Prominent In Both Migraine And Ibs
One specific player in both migraine and IBS is the brain chemical serotonin. Serotonin is a major neurotransmitter of the gastrointestinal tract that plays a relevant part in IBS as well as migraine, Dr. Chait says.
Because of that common denominator, any medication prescribed to improve migraine that targets serotonin and thats typically an antidepressant may have a positive or negative impact on the IBS, says Spears. This would work the other way around, too: If someone has IBS and is put on a medication with a serotonin target, it would have an impact on migraine, he says.
Very often, the effects of the medication track together that is, both conditions will improve, or both conditions will worsen, as a result of the drug, says Spears.
Migraine Prodrome And Dopamine
During the migraine prodrome , people with migraine disease are hypersensitive to dopamine agonists. Dopamine agonists are a compound that activates dopamine receptors.
This can cause some of the prodrome symptoms we can experience with a migraine attack:
According to research in 2008, these specific dopaminergic prodrome symptoms occur in about 20 percent of people with migraine disease.3
I am not sure how accurate that is, given how variable migraine symptoms can be over time in my experience. What I take away from that research isn’t how many people experience it but that those are specific dopaminergic prodrome symptoms we can have.
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Symptoms Of Endometriosis: Are Migraines Common
Endometriosis is one of the most common health issues experienced by women.
Its symptoms are all too familiar:
- Painful periods
But have you ever wondered if your migraines might also be a part of that list?
Are migraines a symptom of endometriosis?
Or are those of us with endometriosis just at a higher risk for having migraine headaches?
A 2018 study showed that 69.3% of adolescent girls diagnosed with endometriosis also experienced endometriosis migraines.
How To Balance Your Hormones To Reduce Migraines
Understanding the root cause of your migraines is essential if you want long-lasting relief. If you have been diagnosed with PCOS or endometriosis, or have had issues with hormone balance in the past, getting your hormones in check is the first step to a pain-free life. Here are three natural ways you can improve your hormone balance and fight migraines from the root!
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Endometriosis And Autoimmune Conditions
Researchers are searching for the root cause of endometriosis. Its thought that people who have endometriosis may have abnormal immune system responses. This could either stem from endometriosis, or the condition itself may be a result of this factor. There are likely many things related to triggering this condition.
A of 298 women found a significant correlation between endometriosis and autoimmune thyroiditis , with some less certain correlations found with other autoimmune conditions.
A few reviews of studies, including one from
endometrioid and clear-cell subtypes . These are rare types of cancers, so the likelihood of developing them is small whether you have endometriosis or not.
If youre concerned about risk, talk with your doctor. They can assess your other risk factors, such as family history, and work with you to develop a preventive screening plan.