Which Migraine Medications Are Safe To Use While Breastfeeding
Although it is safest to avoid all medications if breastfeeding, this is not always feasible. Therefore, to avoid unwanted side effects in the breastfeeding infant, medications should be used at the lowest effective dose and for the shortest duration. Generally, the same medications used during pregnancy can be continued after delivery and while breastfeeding. An exception is aspirin which may cause bleeding problems and Reye’s syndrome in the nursing baby and should therefore be avoided. Mothers who must take medications should also consider not breastfeeding.
Divalproex should not be used in patients with liver or pancreatic disease.
What Are The Different Types Of Migraine Medications
Migraine medications fall into two major categories.
- The first contains drugs that abort or stop migraines from progressing once they begin. The earlier these drugs are used in a migraine attack, the better they work.
- The second category contains drugs that prevent migraines from happening.
- Or combinations of these
One drawback to using analgesics and NSAIDs is that taking them daily can make headaches worse due to medication overuse.
Prescription drugs used to provide relief from pain include
- NSAIDs and
Like over-the-counter medications, prescription drugs often come in combinations.
- A barbiturate called butalbital is often used in combination with acetaminophen, and
- caffeine with or without codeine .
While analgesics, NSAIDs, and narcotics relieve pain, they don’t address the underlying physiology — primarily the dilation of blood vessels in the brain. Two classes of migraine drugs are:
- ergotamines and
Ergot alkaloids — such as ergotamine tartrate and dihydroergotamine mesylate — are potent drugs that constrict blood vessels. Because nausea is a possible side effect of these migraine drugs, some people take ergotamines in combination with other drugs to prevent nausea.
Rated For Headache Report
Got prescribed 500mg of Naproxen for my headaches and they actually did help to relieve my pain for the most part. However, I started experiencing side effects just one day after my first dose. I stopped taking them after my second dose, which was 3 days ago, and Ive still been dealing with abdominal pain , nausea, chills and vomit. So not only do I have these new problems but I still have my headaches! Avoid this drug at all costs!!
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Strongest Migraine Medication Over
When discussing strength, we often refer to how much of a medication is given per dose.
Many of these OTC migraine medications are given in high doses. For example, the recommended dosages for aspirin and acetaminophen are typically around 1,000 mg.
However, when thinking about strength, you may also be considering how strongly these medications act against your migraine symptoms.
In this case, an argument can be made for the aspirin, acetaminophen, and caffeine combination. Older research has found that the combination of these three ingredients has a greater effectiveness than each individual ingredient alone.
Overall, its important to remember that the medication that most effectively alleviates acute migraine symptoms can vary by person. Because of this, focus on finding the treatment that best addresses your symptoms.
When To Worry About A Headache
Most headaches respond to self-care, OTC pain relievers, or medication your doctor prescribes. For some headaches, though, its best to promptly seek medical advice. Warning signs include a headache that:
- is unusually severe or steadily worsens
- follows a blow to the head
- is accompanied by fever, stiff neck, confusion, decreased alertness or memory, or neurological symptoms such as visual disturbances, slurred speech, weakness, numbness, or seizures.
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What Is The Role Of Naproxen Sodium In The Management Of Migraine Headache
The NSAID naproxen sodium has also been used for prophylaxis. In controlled clinical trials, naproxen sodium demonstrated better efficacy than placebo and similar efficacy to propranolol. However, this agent should be reserved for short-term use, such as for menstrual migraines. Tolfenamic acid has also been tried for migraine prophylaxis, but its clinical efficacy is not as good as that of beta blockers, valproate, or methysergide.
When Tylenol Or Advil Fails
If you don’t obtain headache relief from a dose of Tylenol or an NSAID, a next practical choice would be to consider a two-tablet dose of caffeine combined with a pain reliever, such as Excedrin Extra Strength .
For some people, starting off with a combination of analgesic and caffeine may even be better for easing an episodic tension-type headache than a simple analgesic . That said, you may experience more side effects, such as an stomach upset or dizziness .
However, remember that a combination analgesic like Excedrin contains both aspirin and acetaminophen. Be sure to stay within recommended daily limits, especially if you combine it with other types of medication.
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Is There A Best Over
It depends. Every individual is different. One person may find that acetaminophen works very well to ease their symptoms, while another may note that ibuprofen is most effective for them.
You may need to try several different types of OTC medications for migraine before you find one thats effective.
Its also possible that OTC medications wont effectively alleviate your symptoms, particularly if you experience severe migraine. In this case, a doctor can work with you to recommend a prescription medication that may be more effective.
How The Intervention Might Work
NSAIDs act by inhibiting the activity of cyclooxygenase , now recognised to consist of two isoforms , which catalyses the production of prostaglandins, which are responsible for pain and inflammation. Naproxen inhibits both COX isoforms. Prostaglandins mediate a variety of physiological functions, including maintenance of the gastric mucosal barrier, regulation of renal blood flow, and regulation of endothelial tone, and they also play an important role in inflammatory and nociceptive processes. Naproxen is thought to inhibit central sensitisation by attenuating meningeal inflammation and preventing central sensitisation arising from glial cells in the brain stem. In one study, naproxen suppressed central trigeminal neurons in an animal model of intracranial pain .
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How Does This Medication Work What Will It Do For Me
Naproxen belongs to the group of medications called nonsteroidal anti-inflammatory drugs . It is used to treat the symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and juvenile rheumatoid arthritis. It is also used for the relief of minor aches and pains in muscles, bones, and joints mild-to-moderate pain accompanied by inflammation in injuries and menstrual cramps.
It relieves pain and reduces swelling and inflammation by reducing a substance in the body that leads to inflammation and pain. If immediate relief of pain is desired, the long-acting forms of naproxen are not recommended as they release the medication over a longer period of time.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Who Should Not Take This Medication
Do not use this medication if you:
- are allergic to naproxen or any ingredients of this medication
- are allergic to ASA or other NSAIDs or have had allergic symptoms caused by these medications
- are breast-feeding
Do not give naproxen suspension to children less than 2 years of age.
Do not use the suppository form of this medication if you:
- have any inflammatory lesions of the rectum or anus
- have recently had rectal or anal bleeding
Do not give the suppository or tablet form of this medication to children under 18 years of age.
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Can I Take Naproxen With Other Migraine Medications
You can use naproxen alongside other migraine medications like sumatriptan and rizatriptan . Sometimes naproxen already comes in the same pill as your other migraine medicine, so be sure to know the ins and outs of everything youâre taking. You can take naproxen with preventive migraine medicine too.
Data Collection And Analysis
Two review authors independently assessed trial quality and extracted data. We used numbers of participants achieving each outcome to calculate risk ratio and numbers needed to treat for an additional beneficial outcome or for an additional harmful outcome compared with placebo or a different active treatment.
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What Causes Tension Headaches
Stress may cause tension headaches, and smoking may also increase the risk for tension headaches. The exact cause of tension headaches, however, is unknown.
A chronic daily headache is most often a rebound headache. These are brought on by overusing headache medicines. If you use a pain reliever for your headaches more than two times a week, you may get rebound headaches. Chronic daily headaches can also occur in people with migraine who use pain medicine often.
Risk Of Bias In Included Studies
Methodological quality, assessed using the Oxford Quality Scale, was good in all studies. One study scored 5/5 , three scored 4/5 , and two scored 3/5 . Points were lost due to failure to report adequately the method of randomisation or blinding, or both, although it is likely that these were satisfactory as the trials are recent and would have been carried out in dedicated clinical trial facilities. Full details are in the table.
In addition, we created a Risk of bias table, which considered sequence generation, allocation concealment, blinding, incomplete outcome data, and study size . Only one study adequately reported the method of allocation concealment . No study had substantial amounts of missing data, and no study was considered to be at high risk of bias.
Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
Which Migraine Medications Are Safe To Use During Pregnancy
Migraine headaches may become less frequent during pregnancy. However, in rare cases migraines may appear for the first time during pregnancy or become worse. Non-drug therapies are considered to be safer during pregnancy, they should be tried first. Non-drug therapies such as relaxation, sleep, massage, ice packs, and lifestyle changes are considered first-line options during pregnancy.
If drug treatment is required, acetaminophen is usually the treatment of choice. When used appropriately, acetaminophen treatment does not affect the pregnancy or the unborn baby.
Nonsteroidal anti-inflammatory drugs are considered second-line options and thought to be safest in the second trimester. They should not be used near the time of birth. Opioids are third-line options. Prolonged use of opioids may cause addiction and dependence in mothers and child.
Triptans are reserved for moderate-to-severe symptoms in women who have failed to adequately respond to other treatments. Sumatriptan is the oldest and most studied triptan in pregnancy. A pregnancy registry for sumatriptan did not find an increased risk of birth defects or miscarriage in 600 patients who were treated with sumatriptan during pregnancy.
Ergotamines should not be used during pregnancy as they may potentially induce hypertonic uterine contractions and vasospasms/vasoconstrictions which can cause harm to the unborn baby.
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What Is The Most Important Information I Should Know About Naproxen And Sumatriptan
You should not use this medicine if you are allergic to naproxen or sumatriptan , or if you have:
- heart problems, uncontrolled high blood pressure
- a history of heart attack or stroke
- Wolff-Parkinson-White Syndrome or other heart rhythm disorder
- blood circulation problems
- a history of asthma or severe allergic reaction after taking aspirin or an NSAID
- severe liver disease or
- if you are in late pregnancy.
Naproxen can increase your risk of fatal heart attack or stroke, even if you don’t have any risk factors. Do not use this medicine just before or after heart bypass surgery .
Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using naproxen and sumatriptan, especially in older adults.
Do not use naproxen and sumatriptan if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.
Do not take naproxen and sumatriptan within 24 hours before or after using another migraine headache medicine, including:
- sumatriptan tablets, injection, or nasal spray
- almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, or zolmitriptan or
- ergot medicine such as ergotamine, dihydroergotamine, or methylergonovine.
Tell your doctor if you have ever had:
Who Can And Cannot Take Naproxen
Most adults can be prescribed naproxen.
It can also be prescribed to children to treat:
- muscle and bone disorders for babies from 1 month
- diseases of the joints for children from 2 years
- period pain for children under 15
Adults and teenagers aged 15 and over can buy it from a pharmacy for period pain.
Naproxen is not suitable for certain people. Tell your doctor or pharmacist if you:
- have had an allergic reaction to naproxen or any other medicines in the past
- have had an allergic reaction to aspirin or other non-steroidal anti-inflammatory medicines , such as ibuprofen
- have or have had stomach ulcers, bleeding in the stomach or intestines, or a hole in your stomach
- have a blood clotting disorder
- are pregnant, planning to become pregnant, or breastfeeding
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For What Conditions Are Migraine Medications Used
Some of the migraine medications used to treat or prevent migraine headaches are also used for other conditions. Here are the pain reliever medications for migraine therapy.
There are some migraines drugs, though, that are used because they directly target the pain pathways associated with migraine headaches rather than pain pathways in general.
What Are Some Risks With Otc Migraine Medications And Who Should Avoid Them
With all OTC migraine medications, theres a risk of developing whats called a medication overuse headache . MOH is a headache that happens if you use OTC migraine medications for too long, or more than 10 to 14 days a month. If you find yourself needing migraine relief this often or more, talk to your healthcare provider about whether you might need a stronger prescription migraine treatment.
In addition to preventing MOH, youll want to take a few more precautions depending on the specific ingredient your OTC migraine treatment includes.
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Who Shouldn’t Take Nsaids
While NSAIDs are generally considered safe and effective, there are people who should consider other migraine treatments. Namely:
- People who have asthma
- People who are breastfeeding, pregnant, or planning to become pregnant
- People who have heart disease, high blood pressure, liver cirrhosis, or kidney disease
- People who have a history of stomach conditions
- People who are taking blood thinners or diuretics
That said, everyone’s body reacts to medication differently and you should speak to your doctor about your specific needs.
How To Use Sumatriptan
Take this medication by mouth at the first sign of a migraine as directed by your doctor, with a full glass of water . Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take this medication with food, milk, or an antacid. Do not break, crush, or chew the tablet.
The dosage is based on your medical condition, age, and response to treatment. If there is no improvement in your symptoms, do not take more doses of this medication before talking to your doctor. If your symptoms are only partly relieved, or if your headache comes back, you may take another dose at least two hours after the first dose. Do not take more than 2 doses in a 24-hour period.
If you have a higher risk for heart problems , your doctor may perform a heart exam before you start taking this medication. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects . Talk to your doctor for details.
If you are using drugs for migraine attacks on 10 or more days each month, the drugs may actually make your headaches worse . Do not use medications more often or for longer than directed. Tell your doctor if you need to use this medication more often, or if the medication is not working as well, or if your headaches get worse.
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What Are The Possible Side Effects Of Nsaids
While NSAIDs are generally considered safe, like many medications, there are potential side effects. Some of the common side effects include:
- bloating, constipation, diarrhea, gas
- nausea or vomiting
- stomach pain
You should immediately contact your doctor if you experience signs of serious allergic reaction, dizziness, or difficulty breathing while taking these medications.