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Are Migraines And Autoimmune Disease

When To See A Healthcare Provider

4 factors that trigger migraines headaches and autoimmune disease

If you’re worried you may be experiencing symptoms of an autoimmune condition, be sure to see a healthcare provider for a comprehensive evaluation, which will include a thorough physical examination, blood tests, and possibly imaging tests.

If your primary care or family healthcare provider suspects an autoimmune process, you will likely be referred to a specialist, such as a rheumatologist , an endocrinologist , or a gastroenterologist .

Migraine And Inflammatory Bowel Disease

The two main forms of IBD are ulcerative colitis and Crohns disease . These diseases are characterized by defects in the barrier function of the intestinal epithelial layer and the mucosal immune system . Factors that may trigger IBD are antibiotics, non-steroidal anti-inflammatory drugs, stress, and infection. All these factors decrease the mucosal barrier integrity, modulate the immune response, and change the luminal microenvironment, providing the susceptibility to inflammation .

Data about possible correlations between migraine and IBD are scarce. To our knowledge, only two studies investigated the comorbidity between migraine and IBD. In the first study done by Ford et al., 100 patients with Crohns disease or ulcerative colitis were selected from the Gastroenterology clinic at the University of North Carolina . The prevalence of migraine in the IBD patients was 30%. This prevalence rate is higher than the US population basal rate of 18.2% for females and 6.5% for males. In the Crohns disease patients migraine was more prevalent than in the ulcerative colitis patients . In the second study, 111 patients with IBD were questioned in a survey . Prevalence of self-reported migraine was higher in these subjects compared with controls . No reports in the literature were found showing a reduction in migraine frequency or severity with improvements of inflammatory bowel symptoms.

Migraines And Autoimmune Disease

I dont think its coincidence that autoimmune disease and migraines affect mostly women.

Its very common for migraine sufferers to also have autoimmune symptoms.

Even more common for migraine sufferers to display Lupus symptoms.

I personally deal with Hashimotos and lupus symptoms with migraines.

Most autoimmune diseases have migraines listed as a symptom and its a common complaint among women.

Seeing how closely these are connected prompted me to try the AIP Diet for my migraines.

The AIP diet greatly reduces inflammation so I didnt see how it could make my migraines worse.

It also cuts out any foods that you could possibly be allergic to so surely that will reduce migraines as well.

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How Should I Detox

Now that you know detoxing is the way to go comes the time to take action. But what does detox truly mean? In the last few years, it has become a buzzword, with many using the term without really knowing what it refers to. Heres a short and simple explanation: youll need to try and flush toxins out of your system by changing your diet and lifestyle, if necessary.

For example, a diet with organic vegetables and fruits, rich in antioxidants can help your body look and feel better. Lets take a closer look at some tips to detox and do away with toxins for good:

  • Modify your diet to avoid foods with pesticides. And if youre not sure what foods to avoid and which ones to add, you can check out the Environmental Working Groups list of the foods with the highest and lowest levels of pesticide . For instance, strawberries and spinach are at the top of the list, so it may be a good idea to buy organic to help your body detox from pesticides. And here we share with you some recipes of delicious smoothies to prepare for a successful detox!
  • Increase your water intake to promote toxin elimination. Urine is one of the main ways through which we eliminate toxins, so make sure you drink enough water each day. Plus, the best way to increase your water intake is to use a filter to avoid possible contamination. And if you are interested in eliminating toxins through sweating, you can also visit saunas or exercise with intensity.
  • Karen V, one of our happy clients, claims:

    Well Worth It

    What Questions Should I Ask My Healthcare Provider About Autoimmune Diseases

    Ive been having chronic migraines that have consistently ...

    Its helpful to have some questions ready to ask before you see your provider. Examples to consider include:

    • Do I have an autoimmune disease?
    • What tests should I go through?
    • What type of autoimmune disease do I have?
    • Do I need to see a specialist?
    • What specialist should I see?
    • Whats the best treatment for me?
    • Should I let my family members know that I have an autoimmune disease?

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    The Connection Between Migraines And Other Chronic Illness

      Having frequent migraine headaches is bad enough, but a surprising number of sufferers also have other chronic illnesses to complicate matters and that add to their suffering. Sometimes, the illnesses are linked or have similar symptoms and causes. Recognizing both, and getting the correct diagnosis in all cases can help patients understand whats happening to them, which leads to more effective coping strategies and pain management.

      Two of the most common chronic illnesses that plague migraine sufferers are fibromyalgia and lupus.

      Types Of Migraine Auras Visualized And Explained

      Keep in mind, it’s difficult to sort out the intricate connection between migraine and cardiovascular disease, especially considering there are numerous factors that may increase a person’s chance for having a stroke or a heart attack such as smoking, the use of oral contraceptives, high blood pressure and cholesterol, and a family history of heart disease.

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      Migraine With Brainstem Aura


      Migraine with brainstem auraCACNA1A

      • Fainting
      • Loss of consciousness

      This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.


      Percent of people who have these symptoms is not available through HPO


      If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.

      Role For Gut Barrier Function In Migraine

      Painful headaches lead to brain disease diagnosis

      This overview of the literature suggests the existence of a rather strong relationship between GI disorders and migraine. One of the links between inflammatory diseases and migraine are enhanced pro-inflammatory immune responses . In intestinal disorders characterized by an increased intestinal permeability like IBS, IBD, and celiac disease enhanced pro-inflammatory immune responses have been reported . Enhanced levels of pro-inflammatory cytokines like tumor necrosis factor alpha and interleukin 1 in serum of migraine patients have been found during migraine attacks . These cytokines can act on the nociceptors of the trigeminal nerve, causing migraine. Also statistical significant associations have been reported between migraine and a wide range of inflammatory disorders like asthma, obesity, metabolic syndrome, allergies, and GI diseases . A strong trigger of pro-inflammatory immune responses is the leakage of lipopolysaccharides from the intestinal lumen into the circulation. Enhanced levels of LPS can enter the circulation when the intestinal permeability is increased .1). Depending on genetic susceptibility, pro-inflammatory responses can occur in different parts of the body, e.g., in case of migraine on the nociceptors of the trigeminal nerve.

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      Andhealth The Digital Health Company For Reversing Migraine And Autoimmune Diseases Raises $57 Million In Financing For Growth

        AndHealth today announced the companys closure of more than $57 million in financing by leading technology investor Francisco Partners, with participation from the American Medical Associations venture capital arm Health 2047, Kirkland & Ellis and Twofold Ventures.

        AndHealth is led by former CoverMyMeds co-founder and CEO Matt Scantland and the team that helped grow healthcare technology company CoverMyMeds from inception to its $1.4 billion acquisition by McKesson in 2017.

        Virtual Centers of Excellence to Reverse Migraine and Autoimmune Diseases

        The companys first offering is a Virtual Center of Excellence for the reversal of migraine. Shortly, AndHealth will launch a second VCOE for autoimmune diseases, including rheumatoid arthritis, psoriasis, ulcerative colitis and Crohns. These are debilitating, costly, and widely prevalent conditions affecting roughly 30 million working-age people, the majority of whom are women who have suffered from a lack of good treatment options. The company believes it is the first large-scale digital health company to provide root cause medical care for these illnesses.

        Helping Employers Reduce Health Costs, Unlock Productivity, and Achieve DEI Objectives

        A More Effective Approach to Engaging Employees in their Healthcare

        Clinical Study Proves Companys Results

        Collaborating with the Healthcare System to Transform How Chronic Illness is Treated

        About AndHealth

        About Francisco Partners

        About Health2047

        What Is Autoimmunity How Is It Connected To Vestibular Disorders

        Parts of the immune system, working constantly and behind the scenes, patrol the body in search of foreign invaders and relentlessly attack them once found. On rare occasions, in some people the immune system runs amok, identifies the body itself as foreign, and launches a lethal attack. This self-attack is referred to as an autoimmune reaction. In some cases, the reaction takes place in the inner ear, which is called Autoimmune Inner Ear Disease.

        The immune system can attack just the ear, attack the ear and some other body part like the eye, or attack the entire body . An autoimmune reaction also creates debris. Even if the ear is not being directly attacked, it can end up with debris transported from distant locations and deposited by the circulation. This debris in the ear can cause problems.

        Some autoimmune disorders that can affect the ear include Cogans syndrome, relapsing polychondritis, polyarteritis nodosa, Wegeners granulomatosis, systemic lupus erythematosus, ulcerative colitis, Sjogrens syndrome, and rheumatoid arthritis.

        No slam-dunk sort of diagnostic test exists for this type of ear problem. The best tests, such as the 68-kD antigen, are expensive and not widely available. Most tests can easily be positive when there isnt an autoimmune problem and negative when there is the tests arent as accurate as one would like. Sometimes the diagnosis is made only if a favorable response is seen to drug treatment.

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        The Immune System And Headache

        The Pain Practitioner

        The involvement of the immune system in chronic headache has been speculated upon since the 1970s. 2,3 Various components of the immune system have been examined in relation to headache. 4,5 While great strides have been made in advancing our understanding of neuroimmunology, the complexities of the system make its specific role in headache pathology unclear. This paper describes some of the key elements in the immune system and their relation to headache pathogenesis.

        Neuroinflammatory Mechanisms Involved In Headache

        Migraines and Autoimmune Disease Connection

        Nowadays, the relevance of the contribution of neuroinflammation in the pathophysiology of several painful conditions, including migraine, is widely accepted . Neuroinflammation could also be involved in pathophysiological mechanisms of cluster headache but evidence in this regard are limited and dated, whereas its contribution to pathophysiological events underlying tension-type headache is unlikely. Neuroinflammatory mechanisms have also been described in the context of several disorders causing secondary headache, such as post-traumatic stress disorder, chronic stress and traumatic brain injury .

        Peripheral sensitization of the primary afferent trigeminal ganglion neurons leads to the subsequent central sensitization of trigeminal nucleus caudalis second-order neurons which in turn induces the sensitization of third-order neurons in the thalamus. The maintenance of sensitization of neurons in structures involved in the processing of trigemino-cervical nociception is believed to drive the progression from episodic to chronic migraine .

        In the TG, CGRP binds to A delta TG neurons expressing CGRP receptors facilitating nociceptive transmission to second-order neurons in the TNC. Resident glial cells and astrocytes also possess CGRP receptors. The interaction of CGRP with its receptors on these cells induces the release of some pro-inflammatory cytokines such as tumour necrosis factor – and Interleukin -1ß which dramatically amplifies trigeminal nociception .

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        What You Need To Know

        • Vestibular migraine can cause vestibular or balance symptoms with or without an actual headache.
        • There is almost always a history of motion sensitivity since childhood, and migraine headaches at some point in the person’s lifetime, even if they last occurred decades ago.
        • Vestibular migraine isnt fully understood but seems to result from overlapping pathways that modulate pain and vestibular inputs into the brain.
        • Many of the triggers for migraine headaches can cause a vestibular migraine.

        Management Of Headache In Ms Patients

        Management of headache and specifically of migraine in MS patients should be based on a combination of pharmacological and non-pharmacological approaches, as in the non-MS population. Specifically, migraine attacks can effectively be treated with triptans or non-steroidal anti-inflammatory drugs. Preventive drugs should be carefully selected taking into account their known efficacy/side effect profiles as well as any patient comorbidities. Patients with MS and headache should be instructed on the risk of symptomatic drug overuse, stressful conditions which can trigger attacks, and how to achieve more regular sleeping patterns. The presence of depression and/or anxiety in MS patients with headache significantly impair quality of life and it should be incorporated into the overall patient management .

        Anti-CGRP and anti-CGRP receptor antibodies are the first tailored treatment for migraine and have been approved for the preventive treatment of high-frequency episodic migraine and chronic migraine . Furthermore, CGRP antagonists are under evaluation for their symptomatic and prophylactic use in migraine .

        One of the debated issue at this time is the use of these novel therapeutic strategies for migraine in patients affected by autoimmune diseases, specifically MS.

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        How Are Autoimmune Diseases Diagnosed

        Diagnosing an autoimmune disease usually takes healthcare providers longer than it does to diagnose other diseases. This is because many autoimmune diseases have similar symptoms with each other and with other diseases. You can help your healthcare provider with the diagnosing process by bringing the following to your appointment:

        • A detailed list of any symptoms and how long youve had them.
        • A record of your familys health history. Note if anyone in your family has an autoimmune disease.

        In addition to interviewing you about your symptoms, your healthcare provider may do some blood tests to check for autoimmune diseases, including:

        • Antinuclear antibody test .

        Specific symptoms combined with specific blood markers may prove that you have an autoimmune disease.

        Organizations Supporting This Disease

        Heads UP – Episode 22: POTS and Migraine Disease
        • 820 N Orleans, Suite 201 Chicago, IL 60610-3132
        • London, EC4Y 1BN United KingdomTelephone: 0203 9510 150

        These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

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        Why Do They Happen

        Researchers think two things have to happen for you to have an autoimmune disorder. First, you get genes from your parents that make you more likely to have one. Then itâs triggered by something in your environment, like a virus. Because more women are affected than men, doctors think certain hormones may play a role.

        What Are Autoimmune Diseases

        Your immune system is made up of organs and cells meant to protect your body from bacteria, parasites, viruses and cancer cells. An autoimmune disease is the result of the immune system accidentally attacking your body instead of protecting it. It’s unclear why your immune system does this.

        There are over 100 known autoimmune diseases. Common ones include lupus, rheumatoid arthritis, Crohns disease and ulcerative colitis.

        Autoimmune diseases can affect many types of tissues and nearly any organ in your body. They may cause a variety of symptoms including pain, tiredness , rashes, nausea, headaches, dizziness and more. Specific symptoms depend on the exact disease.

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        Autoimmune Disease Risk Factors

        Researchers dont know what causes autoimmune disease, but several theories point to an overactive immune system attacking the body after an infection or injury. We do know that certain risk factors increase the chances of developing autoimmune disorders, including:

        • Genetics: Certain disorders such as lupus and multiple sclerosis tend to run in families. Having a relative with autoimmune disease increases your risk, but it doesnt mean you will develop a disease for certain, says Orbai.
        • Weight: Being overweight or obese raises your risk of developing rheumatoid arthritis or psoriatic arthritis. This could be because more weight puts greater stress on the joints or because fat tissue makes substances that encourage inflammation.
        • Smoking: Research has linked smoking to a number of autoimmune diseases, including lupus, rheumatoid arthritis, hyperthyroidism and MS.
        • Certain medications: Certain blood pressure medications or antibiotics can trigger drug-induced lupus, which is often a more benign form of lupus, Orbai says. Our myositis center also discovered that specific medications used to lower cholesterol, called statins, can trigger statin-induced myopathy. Myopathy is a rare autoimmune disease that causes muscle weakness. Before starting or stopping any medications, however, make sure to talk to your doctor.


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